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US 7,112,785 B2Granted
Method for atmospheric pressure analyte ionization
AssigneeJeol USA, Inc.
InventorsJames A. Laramee, Robert B. Cody
Life of this patent
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Abstract
A nonradioactive atmospheric pressure method for ionization of analytes comprises creating an electrical discharge in a carrier gas thus creating metastable neutral excited-state species. The carrier gas containing the excited-state species is directed into a reactant gas to form ions of the reactant gas. The ionized reactant gas is then directed at the analytes at atmospheric pressure near ground potential to form analyte ions.
Claims16
A method of producing analyte, analyte fragment, and/or analyte adduct ions for mass spectrographic analysis comprising the steps of:
- introducing a carrier gas at atmospheric pressure into a first chamber;
- establishing a potential difference in the chamber creating metastable neutral excited-state species;
- directing the carrier gas and metastable species from the chamber into a reactant gas at atmospheric pressure wherein the metastable species interact with the reactant gas to produce ionized derivatives of the reactant gas;
- and
- directing the carrier-gas/reaction-gas/ionized-derivative mixture into contact with the analyte maintained at atmospheric pressure and near ground potential to form analyte ions, analyte fragment ions, and/or analyte adduct ions.
2 more elements
Dependencies are inferred from the claim text.