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US 7,112,700 B1Granted
Efficient and economic asymmetric synthesis of nootkatone, tetrahydronootkatone, their precursors and derivatives
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsAnne M. Sauer, William E. Crowe, Roger A. Laine, Gregg Henderson
Life of this patent
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Abstract
An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recognized as safe).
Claims13
A process comprising reacting
- with
- and a metal to produce
- wherein X is a halogen atom;
- and wherein R is a hydrogen atom or methyl.
1 more element
A process comprising reacting
- with an alkali metal in the presence of a proton source, whereby tetrahydronootkatone is produced.
Dependencies are inferred from the claim text.