β-ketophosphonates
AssigneeRhodia Consumer Specialties Limited
InventorsChristopher John Harris, Alan Craig Smith, Julie Ann Salter
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Abstract
A method for making β-ketophosphonates by reacting a trialkyl phosphonocarboxylate (such as triethyl phosphonoacetate) with an acyl halide (such as acetyl chloride) in a reaction involving ester formation, followed by decarboxylation, followed by purification. The reaction is run in a single solvent, which is not removed from the reaction mixture until the purification stage. Suitable solvents for this purpose include halogenated aromatic hydrocarbons (such as mono-chlorobenzene).
Claims9
A method for the production of a beta-ketophosphonate by the reaction of a trialkyl phosphonocarboxylate with an acyl halide, said reaction proceeding by way of a first, intermediate ester formation, stage, a second, decarboxylation, stage and a third, purification, stage, in which said reaction is carried out in a single solvent, said solvent not being removed until the third, purification, stage of said reaction.
Dependencies are inferred from the claim text.