Compositions for controlled release of a biologically active agent, and the preparation thereof
AssigneeDelSiTech Oy
InventorsManja Ahola, Eija Säilynoja, Jukka Salonen, Risto Penttinen, Antti Yli-Urpo
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Abstract
A composition for controlled release of a biologically active agent from a carrier. The biologically active agent is heparin or a related biologically active acidic polysaccharide and the carrier is a sol-gel derived silica xerogel. The xerogel is derived from a tetraalkoxysilane such as tetrethoxysilane (TEOS) and part of the tetraalkoxysilane is replaced by an organomodified alkoxysilane, preferably an akylsubsitituted alkoxysilane. The invention also includes a method for the preparation of this composition.
Claims7
A composition for controlled release of a biologically active agent from a carrier, said composition consisting essentially of a biologically active agent which is heparin or a related biologically active acidic polysaccharide, and a carrier which is a sol-gel derived silica xerogel, wherein the xerogel is derived from tetraethoxysilane and part of the tetraethoxysilane is replaced by an alkylsubstituted alkoxysilane, and wherein said composition is biodegradable.
A method for the preparation of a composition for controlled release of a biologically active agent from a carrier, said method consisting essentially of
- a) hydrolysing an alkoxysilane and an alkyl substituted alkoxysilane in the presence of a catalyst,
- b) optionally adjusting the pH to a value suitable for the biologically active agent,
- c) adding the biologically active agent,
- d) allowing the hydroxysilane to polymerize, and optionally
- e) removing water and alcohol formed in the hydrolyzation from the mixture, wherein said composition consists essentially of a biologically active agent which is heparin or a related biologically active acidic polysaccharide, and a carrier which is a sol-gel derived silica xerogel, wherein the xerogel is derived from tetraethoxysilane and part of the tetraethoxysilane is replaced by an alkylsubstituted alkoxysilane, and wherein said composition is biodegradable.
Dependencies are inferred from the claim text.