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US 7,112,338 B2Granted
Cationic liposome delivery of taxanes to angiogenic blood vessels
AssigneeThe Regents of the University of California
InventorsDonald M. McDonald, John W. McLean, O. Gavin Thurston
Life of this patent
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Abstract
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
Claims41
A cationic liposome, comprising:
- cationic lipids;
- and
- a taxane in a lipid bilayer of the liposome, wherein the liposome comprises substantially no taxane crystals, wherein the taxane does not substantially partition from the lipid bilayer, wherein said liposome comprises from about 30 mole % to about 98 mole % cationic lipid, and from about 2 mole % to about 20 mole % taxane, and wherein the liposome has a diameter of from about 100 nm to about 400 nm.
A cationic liposome, comprising:
- a cationic lipid;
- and
- a taxane in an aqueous compartment of the liposome, wherein the liposome comprises substantially no taxane crystals, wherein the taxane does not substantially partition from the aqueous compartment, wherein said liposome comprises from about 30 mole % to about 98 mole % cationic lipid and from about 2 mole % to about 20 mole % taxane, and wherein the liposome has a diameter of about 100 nm to about 400 nm.
Dependencies are inferred from the claim text.