Solid phase dispersion of quinolone or naphthyridonecarboxylic acids
AssigneeBayer HealthCare LLC
InventorFrancisco Cabrera
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Abstract
The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals.
Claims6
A solid phase dispersion comprising a micronized quinolinecarboxylic acid or micronized naphthyridonecarboxylic acid in an insoluble matrix, wherein the insoluble matrix is shellac and wherein the particle size of the solid dispersion is about 20 to about 100 mesh size.
A method of preparing a solid dispersion of a quinolinecarboxylic acid or naphthyridonecarboxylic acid, comprising
- forming a hydrate of micronized quinolinecarboxylic acid or micronized naphthyridonecarboxylic acid,
- mixing the quinolinecarboxylic acid or naphthyridonecarboxylic acid with an insoluble matrix, wherein the soluble matrix is shellac,
- heating the mixture until it flows, and
- micronizing the mixture to reduce particle size, wherein said particle size is about 20 to about 100 mesh size.
Dependencies are inferred from the claim text.