Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides
AssigneeThe United States of America as represented by the Secretary of the Army
InventorGeorge H. Lowell
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Abstract
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccaride and formulated in accordance with the current invention for mucosal delivery such as via the oral or intranasal route is used as a vaccine. Specifically, a vaccine using shigella lipopolysaccharides complexed to proteosomes for such mucosal administration induces IgG and IgA antibodies in sera and in respiratory and intestinal fluids. Furthermore, such antibodies are associated with protection against shigella infection and these vaccines are herein demonstrated to protect against mucosal infection with shigella.
Claims20
An oral or intranasal subunit nonliving vaccine comprising a carrier and an effective amount of an immunogenic hydrophobic complex essentially consisting of proteosomes and at least one non-detoxified antigenic lipopolysaccharide, wherein the effective amount is sufficient, upon being administered orally or intranasally, to protect against infectious or toxic diseases entering at mucosal surfaces.
Dependencies are inferred from the claim text.