Inhibition of complement activation
AssigneeTanox, Inc.
InventorsMichael S. C. Fung, William N. C. Sun, Cecily R. Y. Sun
Life of this patent
Estimating the term…
Abstract
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.
Claims22
A method of inhibiting alternative pathway complement activation in a mammal comprising administering a sufficient amount of an antibody that specifically binds to Factor D, or a Factor D binding fragment thereof, to completely inhibit alternative pathway complement activation at a molar ratio of antibody to Factor D of about 1.5:1.
A method of ameliorating a disease or condition associated with excessive or uncontrolled alternative pathway complement activation comprising administering a sufficient amount of an antibody that specifically binds to Factor D, or a Factor D binding fragment thereof, to completely inhibit alternative pathway complement activation at a molar ratio of antibody to Factor D of about 1.5:1.
Dependencies are inferred from the claim text.