Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AssigneeApplera Corporation
InventorsChunhua Yan, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
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Abstract
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
Claims18
An isolated antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide consists of SEQ ID NO:2.
A method for detecting a polypeptide in a sample, wherein the polypeptide has an amino acid sequence consisting of SEQ ID NO:2, and wherein the method comprises:
- (a) contacting the sample with an antibody that selectively binds to the polypeptide;
- and
- (b) detecting the binding of the antibody to the polypeptide to thereby detect the polypeptide.
A method for detecting a polypeptide in a sample, wherein the polypeptide has an amino acid sequence comprising SEQ ID NO:2, and wherein the method comprises:
- (a) contacting the sample with an antibody that selectively binds to the polypeptide;
- and
- (b) detecting the binding of the antibody to the polypeptide to thereby detect the polypeptide.
An isolated antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide comprises SEQ ID NO:2.
A labeled antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide consists of SEQ ID NO:2, and wherein the antibody is coupled to a detectable substance.
A labeled antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide comprises SEQ ID NO:2, and wherein the antibody is coupled to a detectable substance.
A labeled antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide consists of SEQ ID NO:2, and wherein the antibody is a monoclonal antibody, and further wherein the antibody is coupled to a detectable substance.
A labeled antibody that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide comprises SEQ ID NO:2, and wherein the antibody is a monoclonal antibody, and further wherein the antibody is coupled to a detectable substance.
An isolated antibody fragment that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide consists of SEQ ID NO:2, and wherein the antibody fragment is selected from the group consisting of:
- a) an Fab fragment;
- b) an F(ab')2 fragment;
- and
- c) an Fv fragment.
An isolated antibody fragment that selectively binds to a polypeptide, wherein the amino acid sequence of said polypeptide comprises SEQ ID NO:2, and wherein the antibody fragment is selected from the group consisting of:
- a) an Fab fragment;
- b) an F(ab')2 fragment;
- and
- c) an Fv fragment.
Dependencies are inferred from the claim text.