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US 7,112,320 B1Granted
Solid wound healing formulations containing fibronectin
OwnerAndre Beaulieu, Robert Paquin +1inventors
InventorsAndre Beaulieu, Robert Paquin, Benoit Lariviere
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Abstract
A concentrated solution of a wound healing promoter, in particular fibronectin, is used to develop solid wound dressings. The solid wound dressings containing fibronectin are easy to apply, easy to remove, and deliver fibronectin in a range of physiologically active dosages.
Claims2
A method of producing a wound healing promoter delivery system comprising the steps of
- a) preparing a concentrated solution of fibronectin adjusted to a pH of 8.0 to 11.6:
- b) preparing a solution of an alginate salt;
- c) mixing the solution of step (a) and the solution of step (b) at a pH which is equal to or lower than the isoelectric point of fibronectin when fibronectin is positively charged to form a homogeneous mixture;
- d) adding glacial acetic acid to achieve a final pH of 5.0;
- e) freeze-drying the homogeneous mixture having a pH of 5.0 of step (c) to produce the solid wound healing formulation.
2 more elements
Dependencies are inferred from the claim text.