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US 7,112,218 B2Granted
Tissue engineered blood vessels and apparatus for their manufacture
AssigneeCytograft Tissue Engineering, Inc.
InventorsTodd N. McAllister, Nicolas L'Heureux
Life of this patent
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Abstract
The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling.
Claims20
A TEBV consisting of:
- a) an inner layer of endothelial cells;
- b) a middle layer of denatured fibroblasts;
- and
- c) an outer layer of living fibroblasts.
1 more element
The TEBV of 19 wherein the rolled fibroblast sheet is matured prior to denaturation.
Dependencies are inferred from the claim text.