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US 7,111,502 B2Granted
Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry
AssigneeOcusense, Inc.
InventorsBenjamin Sullivan, Eric Donsky
Life of this patent
Estimating the term…
Abstract
An osmolarity measuring system includes the ability to recognize patterns within the electrical profile of nanoliters of fluid an account for corruptive signals in the electrical profile. These corruptive signals are mainly caused by the mechanical relaxation of the sample fluid after delivery or evaporation across the electrodes.
Claims24
A method of determining the osmolarity of a fluid sample, comprising:
- generating sample data for the fluid sample;
- accounting for transient effects in the sample data;
- determining a value associated with an initial point of placement for the sample fluid once the transient effects are accounted for;
- using the determined value to obtain an osmolarity measurement for the fluid sample;
- and
- accounting for the effects of evaporation before determining the value associated with the initial point of placement.
3 more elements
A method of determining the osmolarity of a fluid sample, comprising:
- generating sample data for the fluid sample;
- accounting for transient effects in the sample data;
- determining a value associated with an initial point of placement for the sample fluid once the transient effects are accounted for;
- using the determined value to obtain an osmolarity measurement for the fluid sample;
- and
- wherein the transient effect is due to mechanical relaxation of the fluid sample.
3 more elements
A method of determining the osmolarity of a fluid sample, comprising:
- generating sample data for the fluid sample;
- accounting for transient effects in the sample data
- accounting for the effects of evaporation before determining the value associated with the initial point of placement;
- determining a value associated with an initial point of placement for the sample fluid once the transient and evaporation effects are accounted for;
- and
- using the determined value to obtain an osmolarity measurement for the fluid sample.
3 more elements
An osmolarity measurement system, comprising:
- a measurement device configured to receive a fluid sample and generate sample data for the fluid sample;
- and
- a processing device coupled with the measurement device, the processing device configured to account for transient effects in the sample data, determine a value associated with an initial point of placement for the fluid sample once the transient effects are accounted for, and use the determined value to obtain an osmolarity measurement for the fluid sample, wherein the processing device is farther configured to account for the effects of evaporation before determining the value associated with the initial point of placement.
An osmolarity measurement system, comprising:
- a measurement device configured to receive a fluid sample and generate sample data for the fluid sample;
- and
- a processing device coupled with the measurement device, the processing device configured to account for transient effects in the sample data, determine a value associated with an initial point of placement for the fluid sample once the transient effects are accounted for, and use the determined value to obtain an osmolarity measurement for the fluid sample, wherein the transient effect is due to mechanical relaxation of the fluid sample, and wherein the processing device is configured to account for mechanical relaxation by determining the number of samples that it takes for the sample data to reach a steady state after the fluid sample is introduced and fitting a curve to a portion of the sample data based on the determination of the number of samples that it takes for the sample data to reach a steady state after the fluid sample is introduced.
Dependencies are inferred from the claim text.