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US 7,109,189 B2Granted
Mitochondrially targeted antioxidants
AssigneesUniversity of Otago, Medical Research Council
InventorsMichael P. Murphy, Robin A. J. Smith
Life of this patent
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Abstract
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.
Claims12
A compound comprising a lipophilic cation moiety, wherein the lipophilic cation moiety is selected from the group consisting of:
- ammonium cations;
- phosphonium cations;
- arsonium cations;
- rhodamine 123;
- JC-1;
- N,N′-bis(2-ethyl-1,3-doxylene)kryptocyanine;
- pyronine Y;
- o-toluidine blue;
- chalcogenpyrilium;
- benzo(a)phenoxazinium and a tribenzyl or triphenyl substituted ammonium or phosphonium cation, covalently coupled to an antioxidant moiety which is a glutathione peroxidase mimetic, wherein the glutathione peroxidase mimetic moiety is selected from the group consisting of:
- benzisoselenazolones, diaryl diselenides and diaryl selenides.
8 more elements
Dependencies are inferred from the claim text.