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AssigneesMerial Limited, Ecole Nationale Veterinaire de Maison Alfort
InventorsMarc Eloit, Bernard Georges Klonjkowski
Estimating the term…
An in vivo replicative and recombined porcine adenovirus characterized in that it comprises a heterologous nucleotide sequence inserted into the porcine adenovirus in conditions enabling the latter to be replicated in vivo and to express the inserted heterologous nucleotide sequence, and in that the adenovirus genome comes from a 3 or 5 serotype (PAV-3 or PAV-5) adenovirus. Insertion occurs in a non-essential zone of the E3 region, preferably with deletion of said zone. The invention also relates to a recombined porcine vaccine comprising one such porcine adenovirus. The invention further relates to a serotype 3 or 5 porcine adenovirus vector that is replicative in vivo and is deleted in a non-essential region of the genome thereof. The invention also relates to a DNA fragment comprising all or part of the referenced SEQ ID NO.5 nucleotide sequence.
A recombinant in vivo replication competent porcine adenovirus (PAV) serotype 5 (PAV-5) which contains at least one heterologous nucleic acid molecule encoding at least one product in the E3 region of the PAV-5 genome, whereby the recombinant PAV replicates in vivo and expresses the product.
A recombinant in vivo replication competent porcine adenovirus (PAV) serotype 5 (PAV-5) which contains at least one heterologous nucleic acid molecule encoding at least one product in the E3 region of the PAV-5 genome, wherein the heterologous nucleic acid molecule is within nucleotides 2064 to 4083 in SEQ ID NO:
A recombinant in vivo replication competent porcine adenovirus (PAV) serotype 5 (PAV-5) which contains at least one heterologous nucleic acid molecule encoding at least one product in the E3 region of the PAV-5 genome, wherein the heterologous nucleic acid molecule is in place of nucleotides 2389–3861 in SEQ ID NO:
An in vivo replication competent porcine adenovirus (PAV) serotype 5 (PAV-5) comprising a nucleotide sequence as depicted in SEQ ID NO:
Dependencies are inferred from the claim text.