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US 7,108,987 B2Granted
Factors participating in degranulation of mast cells, DNAs encoding the same, method of screening of these factors and the inhibitors
AssigneeDainippon Pharmaceutical Co., Ltd.
InventorsTsuyoshi Yamada, Motoharu Ido
Life of this patent
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Abstract
The present invention provides a novel protein that regulates degranulation of mast cells (degranulation regulator), a gene encoding it, a protein (conjugate factor) that interacts with the regulator, a gene encoding it, a screening method of an inhibitor of the degranulation, which uses this degranulation regulator and the conjugate factor, an inhibitor obtained by the screening method and the like.
Claims7
A purified or isolated:
- (a) protein having the amino acid sequence depicted in SEQ ID NO:
- 1, or
- (b) fragment of the protein of the above-mentioned (a), which fragment regulates degranulation of mast cells on its own or by interaction with one or more conjugate factors selected from the group consisting of proteins having the amino acid sequences of SEQ ID NO:
- 7, 9, and 11.
1 more element
Dependencies are inferred from the claim text.