US 7,101,995 B2Granted

Compositions and processes using siRNA, amphipathic compounds and polycations

AssigneeMirus Bio Corporation

InventorsDavid L. Lewis, James E. Hagstrom, Hans Herweijer, Aaron G. Loomis, Sean D. Monahan, Jon A. Wolff

Life of this patent

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Abstract

Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Claims4

Dependent claims

A deliverable composition comprising:

an amphipathic compound, a ethoxylated polyethyleneimine, and a siRNA.

Dependencies are inferred from the claim text.

Facts

Application: 10/157,674Filed 28 May 2002 · us provisional application
Priority: 27 Aug 2001
Published: US 2003/0125281 A13 Jul 2003
Granted: 5 Sep 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification18 codes

C12N 15/1137
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming…: against enzymes
A61K 31/58
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids: containing heterocyclic rings, e.g. danazol,…
A61K 31/74
Medicinal preparations containing organic active ingredients: synthetic polymeric materials
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents

Family

Application60/315,394Us provisional application · filed 27 Aug 2001
Application60/324,155Us provisional application · filed 20 Sep 2001
US 2003/0125281 A1Pre-grant publication · published 3 Jul 2003
US 7,101,995 B2This patent

From the US filing history. Foreign family members aren’t listed.

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