Back to results
US 7,101,709 B2Granted
Methods of screening biological agents
AssigneeNeurospheres Holdings Ltd.
InventorsSamuel Weiss, Brent Reynolds, Joseph P. Hammang, E. Edward Baetge
Life of this patent
Estimating the term…
Abstract
The invention discloses methods of proliferation and differentiation of multipotent neural stem cells. Also provided are methods of making cDNA libraries and methods of screening biological agents which affect proliferation differentiation survival phenotype or function of CNS cells.
Claims11
A method for screening biological agents which affect proliferation, differentiation, survival, phenotype, or function of CNS cells, comprising:
- a) preparing an adherent cell culture of an undifferentiated neural cell population comprising multipotent neural stem cells, wherein a single multipotent neural stem cell is capable of producing progeny that are capable of differentiating into neurons and glia, including astrocytes;
- b) contacting said neural cell population with at least one biological agent, and
- c) determining if said biological agent has an effect on proliferation, differentiation, survival, phenotype, or function of said neural cell population.
Dependencies are inferred from the claim text.