Recombinant Sendai virus
AssigneeDNAVEC Research Inc.
InventorsYoshiyuki Nagai, Atsushi Kato, Fukashi Murai, Tsuneaki Sakata, Mamoru Hasegawa, Tatsuo Shioda
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Abstract
A method for generating Sendai virus particles by transfecting the Sendai virus genome to a host expressing all genes for the initial viral replication has been developed, enabling the genetic manipulation of Sendai virus and effective utilization of said virus as the vector.
Claims17
A recombinant Sendai viral vector containing a Sendai viral genome carrying a foreign gene, wherein said vector allows for the expression in a host cell of both Sendai viral genes contained within said Sendai viral genome and said foreign gene.
A recombinant Sendai viral vector containing a Sendai viral genome in which at least one gene encoding a Sendai viral protein selected from the group consisting of NP, P, and L proteins, is deleted or inactivated, wherein all other Sendai virus genes, other than genes encoding NP, P, and L proteins, are retained.
Dependencies are inferred from the claim text.