PD-1, a receptor for B7-4, and uses therefor
AssigneesDana-Farber Cancer Institute, Inc., Genetics Institute, Inc.
InventorsClive Wood, Gordon J. Freeman
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Abstract
The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in a immune cell resulting in modulation of the immune response.
Claims5
A method for upmodulating an immune response comprising administering an agent that downmodulates signaling via PD-1, wherein the agent comprises an antibody that binds a B7-4 polypeptide comprising the amino acid sequence shown in SEQ ID NO:4, to thereby upmodulate the immune response.
Dependencies are inferred from the claim text.