Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
AssigneesGenentech, Inc., ImmunoGen, Inc.
InventorsSharon Erickson, Ralph Schwall, Mark Sliwkowski, Walter Blattler
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Abstract
The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB receptor antibody-maytansinoid conjugates.
Claims44
A method for the treatment of a tumor in a mammal, comprising the steps of (i) identifying said tumor as being characterized by overexpression of an ErbB2 receptor and as being a tumor that does not respond, or responds poorly, to treatment with an anti-ErbB2 antibody which binds to the 4D5 epitope and which has a growth inhibitory effect on SK-BR-3 cells, and (ii) administering to a mammal having said tumor a therapeutically effective amount of a conjugate of an anti-ErbB2 antibody which binds to the 4D5 epitope with a maytansinoid.
Dependencies are inferred from the claim text.