US 7,096,053 B2 · Internal biochemical sensing device

Abstract

A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer directs light through the optical fiber into the biosensing element. The light excites fluorophores, created by a chemical reaction between analytes and biosensing material within the biosensing element. Emitted fluorescent light is redirected through the optical fiber to the information analyzer. Optical gratings within the filtering member of the information analyzer selectively deflect fluorescent emissions into a cladding layer. Detectors attached to the cladding layer detect the deflected fluorescent emissions and, according to their determined wavelength, report the presence or quantity of specific analytes to the patient on an external display.

Claims10

Dependent claims

A method of manufacturing a component for use in a biosensing device for detecting one or more analytes, including:

providing a transmitting member having a first end and a second end, the second end being configured for operably coupling to an information analyzer, wherein the transmitting member comprises at least a capillary tube having a lumen and an optical fiber, and wherein biosensing materials are applied to the transmitting member first end by injection of the biosensing materials to a capillary tube first end and through the lumen to a capillary tube second end;
applying a biosensing element having one or more biosensing materials to the transmitting member first end;
and
applying a containment matrix to the transmitting member first end wherein the containment matrix substantially surrounds the biosensing materials and wherein the containment matrix is permeable to an analyte to be detected.

1 more element

Dependencies are inferred from the claim text.

Internal biochemical sensing device

Life of this patent

Internal biochemical sensing device

Life of this patent

Abstract

Claims10