OSR-1 nucleic acids and proteins
AssigneeNorthwestern University
InventorsAaron Solomon, Richard Morimoto, Greg Beitel
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Abstract
The present invention relates to water-stress tolerance, in particular to the OSR-1 (osmotic stress resistant-1) protein, and nucleic acids encoding the OSR-1 protein. The present invention provides assays for the detection of OSR-1, and polymorphisms and mutations associated with water stress tolerance. In particular, the present invention relates to compositions comprising small interfering RNA duplexes (RNAi), or vectors that encode dsRNA, that inhibit expression of the OSR-1 gene (e.g. by targeting OSR-1 mRNA), and methods of using these compositions to impair deleterious nematodes.
Claims6
A composition comprising an isolated collection of mutant C. elegans altered in an (OSR-1 gene to reduce sensitivity to osmotic desiccation stress compared to C. elegans not altered in said OSR- 1 gene, wherein said mutant C. elegans comprise a knock-out OSR-1 mutation.
A composition comprising
- a small interfering RNA duplex, or vectors encoding said small interfering RNA duplex, configured to inhibit expression of C. elegans OSR-1 protein, and a nucleic acid transfecting agent.
Dependencies are inferred from the claim text.