HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis

A process for preparing a compound of formula (I-H), or a prodrug, or pharmaceutically active salt or solvate thereof,

• wherein:
• R1 is a 5- or 6-membered mono-cyclic carbocyclic or heterocyclic group, wherein said carbocyclic or heterocyclic group is saturated, partially unsaturated or fully unsaturated and is optionally substituted by at least one substituent chosen from C1-6 alkyl, hydroxyl, C1-6 alkylcarbonyloxy, C6-10 arylcarbonyloxy, and heteroarylcarbonyloxy;
• R2 is C1-6 alkyl substituted with at least one halogen;
• and
• R4, R5, R6 and R7 are independently chosen from H and C1–C6 alkyl;
• comprising:
• reacting a compound of formula (II), wherein Y1 is hydroxyl or a leaving group, with a compound of formula (III), or a salt or solvate thereof,