Nucleic acids encoding opiate receptors
AssigneeThe Research Foundation of State University of New York
InventorsPatrick Cadet, George B. Stefano
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Abstract
The invention provides isolated nucleic acid molecules, host cells that contain an isolated nucleic acid molecule, and substantially pure polypeptides. For example, the invention provides isolated nucleic acid molecules that encode polypeptides having mu3 opiate receptor activity, host cells that contain an isolated nucleic acid molecule that encodes a polypeptide having mu3 opiate receptor activity, and substantially pure polypeptides that have mu3 opiate receptor activity. In addition, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists.
Claims6
An isolated nucleic acid primer for amplifying nucleic acid encoding a sequence of mu3 opiate receptor having higher affinity for morphine than for DAMGO, wherein said primer comprises at least a 15 contiguous nucleotide sequence set forth in SEQ ID NO:1 with or without a single nucleotide insertion, single nucleotide deletion, or single nucleotide substitution.
Dependencies are inferred from the claim text.