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US 7,094,889 B2Granted
AGE-1 polypeptides and related molecules and methods
AssigneeThe General Hospital Corporation
InventorsGary Ruvkun, Jason Morris, Heidi Tissenbaum
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Abstract
Disclosed are substantially pure AGE-1 polypeptides and purified DNAs, vectors, and cells encoding those polypeptides. Also disclosed are methods for determining longevity and isolating antagonists using the AGE-1 sequence.
Claims9
A purified and isolated DNA which encodes an AGE-1 polypeptide, said polypeptide comprising the sequence of SEQ ID NO:
- 1.
A method of identifying an AGE-1 modulatory compound that is capable of decreasing the expression of an AGE-1 gene, said method comprising the steps of:
- (a) providing a nematode cell expressing its endogenous AGE-1 DNA;
- (b) contacting said nematode cell with a candidate compound;
- (c) isolating a sample from said nematode cell after contacting;
- and
- (d) measuring AGE-1 gene expression in said sample, wherein a decrease in AGE-1 gene expression in said sample isolated from said nematode cell following contact with said candidate compound, compared to AGE-1 gene expression in a sample isolated from a nematode cell that is not contacted with said candidate compound, identifies said candidate compound as a compound that is capable of decreasing AGE-1 gene expression.
2 more elements
Dependencies are inferred from the claim text.