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US 7,094,885 B2Granted
Skeletal-targeted radiation to treat bone-associated pathologies
AssigneeNeoRx Corporation
InventorAlan R. Fritzberg
Life of this patent
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Abstract
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid.
Claims12
A therapeutic method for treating a bone-associated cancer in a human patient comprising:
- (a) parenterally administering a dose of 153Sm-EDTMP by intravenous infusion or injection in an aqueous vehicle comprising an effective antiradiolytic amount of pharmaceuticably acceptable radio protectant;
- (b) administering a dose of about 140–200 mg/m2 of melphalan to said patients, wherein steps (a) and/or (b) are effective to suppress the bone marrow of a human patient;
- and
- (c) providing the patient with bone marrow transplantation and/or restoration;
- wherein the patient is not subjected to total body irradiation in conjunction with the therapeutic method.
2 more elements
Dependencies are inferred from the claim text.