Decorin proteoglycan inhibitor of fibrinogen blood clotting
AssigneeThe Texas A&M University System
InventorsMagnus Höök, Tracey A. Dugan
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Abstract
The present invention provides compositions and methods of inhibiting fibrin(ogen) clot formation by utilizing decorin proteoglycan as an anticoagulating and antithrombotic agent. The decorin proteoglycan comprises a decorin core protein or a fragment thereof covalently linked to a galactosaminoglycan polysaccharide. The decorin core protein acts as an anticoagulant and as a carrier for the delivery of an antithrombotic galactosaminoglycan to fibrinogen. Fibrin clotting is inhibited by the decorin proteoglycan in a concentration-dependent fashion.
Claims8
A recombinant anticoagulating and antithrombotic decorin proteoglycan with the sequence of SEQ ID NO:
- 2 linked to a galactosaminoglycan polysaccharide.
Dependencies are inferred from the claim text.