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US 7,094,878 B2Granted
Aortic carboxypeptidase-like polypeptide
AssigneePresident and Fellows of Harvard College
InventorsMu-En Lee, Matthew D. Layne, Shaw-Fang Yet
Life of this patent
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Abstract
The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.
Claims5
An isolated polypeptide comprising an amino acid sequence which is at least 87% identical to SEQ ID NO:2 over the entire length of SEQ ID NO:
- 2 and which amino acid sequence comprises
- (a) a discoidin domain comprising amino acids 385–540 of SEQ ID NO:2;
- (b) a lysine-rich/proline-rich domain comprising amino acids 117–164 of SEQ ID NO:
- 2;
- and
- (c) a carboxypeptidase domain comprising amino acids 562–969 of SEQ ID NO:2, wherein an amino acid substitution in said polypeptide is conservative with respect to SEQ ID NO:2 and wherein the absence of said polypeptide is associated with gastroschisis.
3 more elements
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.