Polypeptide that interacts with heat shock proteins
AssigneeBoard of Regents, The University of Texas System
InventorsWinston Campbell Patterson, Carol A. Ballinger
Life of this patent
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Abstract
An isolated polypeptide having negative regulating activity for a heat shock protein is provided. Also provided is an isolated nucleic acid encoding the polypeptide of the invention, methods for identifying inhibitors of the polypeptide and recombinant preparation of the polypeptide. Also provided are compositions such as inhibitor compositions.
Claims12
An isolated polypeptide comprising SEQ ID NO:
- 2.
An isolated polypeptide comprising the amino acid sequence of amino acids 1–197 of SEQ ID NO:2, wherein the polypeptide binds to the carboxyl-terminal domain of the heat shock protein Hsc70.
An isolated polypeptide comprising SEQ ID NO:7.
An isolated polypeptide encoded by a nucleic acid that hybridizes to the nucleic acid complement of SEQ ID NO:1 under hybridization conditions of 0.015 M NaCl/0.0015 M sodium citrate (SSC) and about 0.1% sodium dodecyl sulfate (SDS) at about 50° C. to about 65° C., wherein said polypeptide comprises at least the amino acid sequence of amino acid residues 1–197 of SEQ ID NO:2, and wherein said polypeptide binds with to the carboxyl-terminal domain of the heat shock protein Hsc70.
An isolated polypeptide comprising the amino acid sequence of amino acids 1–197 of SEQ ID NO:7, wherein the polypeptide binds to the carboxyl-terminal domain of the heat shock protein Hsc70.
Dependencies are inferred from the claim text.