pH-sensitive block copolymers for pharmaceutical compositions
AssigneeLabopharm, Inc.
InventorsVinayak Sant, Jean-Christophe Leroux
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Abstract
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl (alkyl)acrylate-co-(alkyl)acrylic acid) that is capable of forming supramolecular assemblies or micelles under favourable conditions. The supramolecular assemblies or micelles formed from said polymers associate or dissociate reversibly upon changes in the environmental pH. The pharmaceutical compositions of the present invention contain hydrophobic drugs, cations or polycationic compounds, which can be delivered to the body by oral route or other routes of administration.
Claims23
A pharmaceutical composition comprising:
- a diblock copolymer of poly(ethylene oxide) and poly(butyl (alkyl)acrylate-co-(alkyl)acrylic acid);
- and at least one biologically active agent.
Dependencies are inferred from the claim text.