Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use

A compound of the formula I

• wherein
• R1, R2 are each, independently of one another, H, aryl, COOH, (C1–C6)-alkylene-COOH, —COO(C1–C6)-akyl, (C1–C6-alkylene-COO(C1–C6)-alkyl, (C1–C6)-alkyl, (C2–C6)-alkenyl, (C1–C6)-alkylene-aryl, heterocycle, (C1–C6)-alkylene-heterocycle, CF3, OCF3, CN, (CH2)1-6—OH, O—(C1–C6)-alkyl, CO—(C1–C6)-alkyl, —C(O)O-alkyl, COOH or CON(R9)(R10),
• wherein said aryl, (C1–C6)-alkylene-aryl, heterocycle and (C1–C6)-alkylene-heterocycle radicals are optionally substituted one or more times by F, Cl, Br, (CH2)0-2OH, (C1–C6)-alkyl, (C2–C6)-alkenyl, (C2–C6)-alkynyl, CF3, OCF3, N(R9)(R10), piperidinone, piperazine, piperazinone, N—(C1–C6-alkylene)piperazine, N—(C1–C6-alkylene)piperazinone, morpholine, thiomorpholine, NO2, CN, O—(C1–C6)-alkyl, S(O)0-2—(C1–C6)-alkyl, SO2—N(R9)(R10), CO—(C1–C6)-alkyl, —COOH, (C1–C6)-alkylene-COOH, COO(C1–C6)-alkyl, (C1–C6)-alkylene-COO(C1–C6)-alkyl, (C3–C10)-cycloalkyl or phenyl,
• wherein said piperidinone, pirazine, piperazinone, N—(C1–C6)-alkylene)piperazine, N—(C1–C6-alkylene)piperazinone, morpholine, thiomorpholine and phenyl are optionally substituted one or more times by F, Cl, Br (CH2)0-2OH, COOH, CN, NO2, —O—(C1–C6)-alkyl, —NH—O—(C1–C6)-alkyl, —(CO)—NH—O—(C1–C6)-alkylene-N(R9)(R10), —(CO)—(C1–C6)-alkyl, —(C1–C6)-alkyl, CF3, OCF3 or N(R9)(R10);
• R3 is H, (C1–C6)-alkyl, (C1–C6)-alkylene aryl, —C(O)-aryl, (C1–C6)-alkylene-heterocycle or CO—(C1–C6)-alkyl,
• wherein said (C1–C6)-alkylene aryl, —C(O)-aryl and (C1–C6)-alkylene-heterocycle radicals are optionally substituted one or more times by F, Cl, Br, (C1–C6)-alkyl, COOH, COO—(C1–C6)-alkyl, CF3 or OCF3;
• R4, R5 are each, independently of one another, H, F, Cl, Br, (C1–C6)-alkyl, CF3, OCF3, NO2, N(R9)(R10), CN, O—(C1–C6)-alkyl, CO—(C1–C6)-alkyl, COOH, (C1–C6)-alkylene-COOH, CON(R9)(R10), (C1–C6)-alkylene-CON(R9)(R10), COO(C1–C6)-alkyl, (C1–C6)-alkylene-COO(C1–C6)-alkyl, S(O)0-2—(C1–C6)-alkyl, S(O)2—N(R9)(R10) or CH2OH, CH2OCH3;
• R6, R7 are each, independently of one another, H, F, Cl, Br, (C1–C6)-alkyl, cyclopropyl, tetrafluorocyclopropyl, or difluorocyclopropyl;
• or
• R6 and R7 together form the group ═CH2;
• R8 is H, CH3, CF3 or CH2OH;
• R9 is H or (C1–C4)-alkyl;
• R10 is H or (C1–C4)-alkyl;
• or
• R9 and R10 form together, with the N atom to which they are bonded, a 3–9 membered ring system;
• and pharmaceutically acceptable salts thereof.