Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

A compound of Formula (I)

• wherein
• T is an aryl ring, optionally independently substituted by [R]n, wherein n is an integer 0–5, and R is hydrogen, aryl, optionally halogenated C1-6-alkyl, optionally halogenated C1-6-alkoxy, C1-6-alkylsulfonyl, carboxy, cyano, nitro, halogen, aryloxy, arylsulfonyl, arylamino, wherein aryl and aryloxy residues are further optionally substituted in one or more positions independently of each other by C1-6-acyl, C1-6-alkylthio, cyano, nitro, hydrogen, halogen, optionally halogenated C1-6-alkyl, optionally halogenated C1-6-alkoxy, amide which is optionally mono- or di-substituted, (benzoylamino)methyl, carboxy, or 2-thienylmethylamino;
• or T is selected from 5-(dimethylamino)-1-naphthyl and phenyl substituted with one or more of benzeneamino, benzylamino and 2-thienylmethylamino;
• R1 is hydrogen or C1-6-alkyl;
• X is CH2 or CO;
• Y is CO;
• B is hydrogen, C1-6-alkyl or dimethylaminomethyl;
• R2 is NR3R4, wherein R3 and R4 are each independently selected from hydrogen, ethyl, isopropyl, n-propyl, optionally halogenated C1-6-alkylsulfonyl, C1-6-alkoxy, 2-methoxyethyl, 2-hydroxyethyl, C1-6-acyl, cyclohexylmethyl, cyclopropanecarbonyl, aryl, optionally halogenated arylsulfonyl or C1-6-alkyl substituted with one or more aryl
• or a salt, hydrate or solvate thereof.