Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions

A compound of the formula 1

• wherein:
• X− denotes an anion with a single negative charge;
• A and B denote —CH═CH—;
• R denotes hydrogen, hydroxy, —C1–C4-alkyl, —C1–C4-alkyloxy, —C1–C4-alkylene-halogen, —O—C1–C4-alkylene-halogen, —C1–C4-alkylene-OH, —CF3, CHF2, —C1–C4-alkylene-C1–C4-alkyloxy, —O—COC1–C4-alkyl, —O—COC1–C4-alkylene-halogen, —C1–C4-alkylene-C3–C6-cycloalkyl, —O—COCF3 or halogen;
• R1 and R2 which may be identical or different denote —C1–C5-alkyl, which may optionally be substituted by —C3–C6-cycloalkyl, hydroxy or halogen, or
• R1 and R2 together denote a —C3–C5-alkylene-bridge;
• R3, R4, R3′ and R4′, which may be identical or different denote hydrogen, C1–C4-alkyl, C1–C4-alkyloxy, hydroxy, —CF3, —CHF2, CN, NO2 or halogen;
• and
• Rx and Rx ′ which may be identical or different denote hydrogen, C1–C4-alkyl, C1–C4-alkyloxy, hydroxy, —CF3, —CHF2, CN, NO2 or halogen or
• Rx and Rx ′ together denote a single bond or a bridging group selected from the class of bridges consisting of —O—, —S—, —NH—, —CH2—, —CH2—CH2—, —N(C1–C4-alkyl)-, —CH(C1–C4-alkyl)- and —C(C1–C4-alkyl)2-;
• or an acid addition salt thereof.