Method of treating breast cancer using a combination of vitamin D analogues and other agents
AssigneeBone Care International, Inc.
InventorsStephen A. Strugnell, Don Wigington
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Abstract
The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the breast, e.g., breast cancer, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
Claims11
A method of synergistically inhibiting the growth of human breast cancer cells, comprising contacting the cells with a first composition which comprises 1α,24-dihydroxyvitamin D2 and a second composition which comprises an agent selected from the group consisting of doxorubicin, cisplatin and paclitaxel or combinations thereof.
Dependencies are inferred from the claim text.