Back to results
US 7,094,764 B2Granted
Substituted benzimidazole-, Benztriazole-, and benzimidazolone-O-glucosides
AssigneeJanssen Pharmaceutica NV
InventorMaud Urbanski
Life of this patent
Estimating the term…
Abstract
This invention relates to to substituted benzimidazole-O-glucosides, benztriazole-O-glucosides, and benzimidazolone-O-glucosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X.
Claims20
A compound of formula (III):
- wherein:
- X is CH, N, or C═O;
- R1 is H or absent;
- R2 is H, F, Cl, OCH3, OCH2CH3, or C1-4 alkyl, CF3, SCH3, substituted or unsubstituted phenyl or NR3R4;
- R3 and R4 are H, C1-6 alkyl, or taken together with the nitrogen atom to which they are both attached form a 5–6 membered heterocyclyl with optionally 1–2 additional heteroatoms independently selected from O, S, or N;
- Q is —(CH2)n— where n is 1 or 2;
- P is H, C1-7 acyl, or (C1-6 alkoxy)carbonyl;
- and
- Z is substituted or unsubstituted, and is selected from C3-7 cycloalkyl, phenyl, 5- or 6-membered heteroaryl having 1 or 2 heteroatoms independently selected from N, O, and S, a biaryl, and a 9- or 10-membered fused bicyclyl or fused heterobicyclyl, wherein said fused heterobicyclyl has between 1 and 4 heteroatoms independently selected from N, O, and S;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.