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US 7,094,761 B2Granted
Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions
AssigneeTheratechnologies Inc.
InventorsKrishna G. Peri, Serge Moffett, Daniel Abran
Life of this patent
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Abstract
A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating elevated intraocular pressure and conditions associated with elevated intraocular pressure, such as glaucoma.
Claims31
A substantially pure peptide compound of Formula I:
- Z1-His-Ile-Ile-Cys-Ser-Pro-Leu-Arg-Z2 I
- wherein:
- Formula I comprises a domain of SEQ ID NO:
- 4;
- Z1 is an N-terminal group of the formula H2N—, RHN— or, RRN—;
- Z2 is a C-terminal group of the formula —C(O)OH, —C(O)R, —C(O)OR, —C(O)NHR, —C(O)NRR;
- R at each occurrence is independently selected from (C1–C6) alkyl, (C1–C6) alkenyl, (C1–C6) alkynyl, substituted (C1–C6) alkyl, substituted (C1–C6) alkenyl, or substituted (C1–C6) alkynyl;
- and
- “-” is a covalent linkage.
6 more elements
A substantially pure peptide compound, said compound being up to 50 amino acids in length and having a domain of Formula II:
- -His-Ile-Ile-Cys-Ser-Pro-Leu-Arg- II (SEQ ID NO:
- 4)
- wherein:
- “-” is a covalent linkage.
1 more element
Dependencies are inferred from the claim text.