Peptides for treatment of inflammation and shock
AssigneeSalpep Biotechnology, Inc.
InventorsRonald Mathison, Joseph S. Davison, Dean Befus, Graham Moore
Life of this patent
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Abstract
Submandibular peptides have been isolated and characterised and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced shock.
Claims28
A method for treating an inflammatory reaction in a mammal comprising administering to the mammal a peptide of the formula:
- X1—R1—X2—R2
- wherein X1 is an aromatic amino acid residue;
- X2 is any amino acid residue;
- and
- R1 is NH2—or an amino acid sequence X3—X4—X5
- wherein X3 is an aliphatic amino acid residue having a side chain hydroxyl group and X4 and X5 are the same or different and are any amino acid residue and wherein R2 is a sequence of 1 to 3 amino acid residues which are the same or different and are aliphatic amino acid residues, or a fragment or derivative of said peptide of the formula R1—X1—X2—R2 effective to treat an inflammatory reaction.
A method for reducing the infiltration of neutrophils into an inflammatory site in a mammal comprising administering to the mammal a peptide of the formula:
- X1—R1—X2—R2
- wherein X1 is an aromatic amino acid;
- X2 is any amino acid residue;
- and
- R1 is NH2—or an amino acid sequence X3 —X4 —X5
- wherein X3 is an aliphatic amino acid residue having a side chain hydroxyl group and X4 and X5 are the same or different and are any amino acid residue and wherein R2 is a sequence of 1 to 3 amino acid residues which are the same or different and are aliphatic amino acid residues, or a fragment or derivative of said peptide of the formula X1—R1—X2—R2 effective for reducing the infiltration of neutrophils into an inflammatory site.
A method for inhibiting activation of neutrophils in a mammal comprising administering to the mammal a peptide of the formula:
- R1—X1—X2—R2
- wherein X1 is an aromatic amino acid;
- X2 is any amino acid residue;
- and
- R1 is NH2—or an amino acid sequence X3—X4—X5
- wherein X3 is an aliphatic amino acid residue having a side chain hydroxyl group and X4 and X5 are the same or different and are any amino acid residue and wherein R2 is a sequence of 1 to 3 amino acid residues which are the same or different and are aliphatic amino acid residues, or a fragment or derivative of said peptide of the formula X1—R1—X2—R2 effective for inhibiting activation of neutrophils.
Dependencies are inferred from the claim text.