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AssigneeDabur Research Foundation
InventorsAnand C. Burman, Sudhanand Prasad, Rama Mukherjee, Anu T. Singh, Archna Mathur, Neena Gupta
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The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acids. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing α, α-dialkylated amino acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptors on target cells. The invention encompasses methods for the generation of these peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.
A method for treating ovarian, colon, lung, oral, pancreatic, or non-small lung cancer, or cancer of the duodenum, or glioblastoma in a mammal comprising administering to the mammal an amount of a vasoactive intestinal peptide analog of the formula (I)
Dependencies are inferred from the claim text.