Aggrecanase
AssigneeAstellas Pharma Inc.
InventorsNoboru Yamajii, Kouichi Nishimura, Kunitake Abe
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Abstract
A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating joint diseases are disclosed. The polypeptide is a novel aggrecanase causative of joint diseases (particularly an OA disease).
Claims3
An isolated polypeptide comprising amino acid sequence of SEQ:
- ID NO:
- 2.
An isolated polypeptide comprising an amino acid sequence having 95% or more homology with the amino acid sequence of SEQ ID NO:
- 2, and exhibiting aggrecanase activity.
An isolated polypeptide consisting of amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.