Nucleic acid delivery
AssigneesCanji, Inc., Innovata Limited
InventorsSusan E. Conroy, Engler Heidrun, Daniel C. Maneval
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Abstract
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
Claims26
A method to deliver a recombinant nucleic acid to a cell, the method comprising intraperitoneally contacting the cell with a solution comprising:
- an adenoviral vector, the adenoviral vector comprising the recombinant nucleic acid,
- about 2%–20% w/v dextrin, and
- about 1%–10% w/v sucrose.
A composition for intraperitoneal delivery of a recombinant adenoviral vector to a cell, the composition comprising a recombinant adenoviral vector in a solution comprising about 2%–20% w/v dextrin and about 1%–10% sucrose.
A pharmaceutical formulation comprising a recombinant adenoviral vector, about 2%–20% w/v dextrin, about 1%–10% sucrose and a divalent cation.
Dependencies are inferred from the claim text.