Insulin and albumin fusion protein
AssigneeAventis Behring GmbH
InventorsReinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gérard Jung, Patrice Yeh
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Abstract
Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
Claims43
A recombinant fusion protein comprising insulin and albumin or an albumin variant, wherein (i) said recombinant fusion protein has a higher plasma stability than unfused insulin, (ii) said recombinant fusion protein retains the therapeutic activity of unfused insulin, and (iii) said albumin or albumin variant is located either at the N-terminus or C-terminus of said recombinant fusion protein.
Dependencies are inferred from the claim text.