Hair follicle growth factor proteins
OwnerSoogyun Kim, Hyun-Jun Janginventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF proteins of the present invention have a characteristic reduced expression in hair follicles derived from alopecia patients and have a stimulatory effect on hair follicle cell proliferation. HFGF proteins may be used to prevent or treat alopecia and to promote or accelerate hair growth and hair follicle repair.
Claims40
An isolated polypeptide having the amino acid sequence of SEQ ID NO:
- 1.
An isolated polypeptide having the amino acid sequence of amino acids 40 to 208 of SEQ ID NO:
- 1.
An isolated polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1.
An isolated nucleic acid molecule that encodes a polypeptide having the amino acid sequence of SEQ ID NO:1.
An isolated nucleic acid molecule that encodes a polypeptide having the amino acid sequence of amino acids 40 to 208 of SEQ ID NO:
- 1.
An isolated nucleic acid molecule that encodes a polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1.
A vector comprising a nucleic acid molecule encoding a polypeptide having the amino acid sequence of SEQ ID NO:1.
A vector comprising a nucleic acid molecule encoding a polypeptide having the amino acid sequence of amino acids 40 to 208 of SEQ ED NO:1.
A vector comprising a nucleic acid molecule encoding a polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:1.
A host cell transfected by a vector comprising:
- a transcription promoter,
- a DNA encoding a polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1, and
- a transcription terminator,
- wherein the promoter is operably linked to the DNA and the DNA is operably linked to the transcription terminator.
A method of producing a polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1 comprising:
- culturing a host cell transfected by a vector comprising a transcription promoter, a DNA encoding the polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1, and a transcription terminator, wherein the promoter is operably linked to the DNA and the DNA is operably linked to the transcription terminator, under conditions such that the polypeptide is expressed;
- and
- isolating said polypeptide from the culture.
A method of producing a polypeptide having the amino acid sequence of SEQ ID NO:1 comprising:
- culturing a host cell transfected by a vector comprising a transcription promoter, a DNA encoding a polypeptide having the amino acid sequence of SEQ ID NO:
- 1, and a transcription terminator, wherein the promoter is operably linked to the DNA and the DNA is operably linked to the transcription terminator, under conditions such that the polypeptide is expressed;
- and
- isolating said polypeptide from the culture.
A method of producing a polypeptide having the amino acid sequence of amino acids 40 to 208 of SEQ ID NO:
- 1 comprising:
- culturing a host cell transfected by a vector comprising a transcription promoter, a DNA encoding the polypeptide having the amino acid sequence of amino acids 40 to 208 of SEQ ID NO:
- 1, and a transcription terminator, wherein the promoter is operably linked to the DNA and the DNA is operably linked to the transcription terminator, under conditions such that the polypeptide is expressed;
- and
- isolating said polypeptide from the culture.
A method for transplanting hair in a subject comprising
- supplementing scalp hair follicles or grafts with a polypeptide having the amino acid sequence of amino acids 69 to 208 of SEQ ID NO:
- 1;
- and
- transplanting the supplemented hair grafts or follicles with the polypeptide to the bald or thinning area of said subject.
Dependencies are inferred from the claim text.