IL-17 receptor like molecules and uses thereof
AssigneeAmgen Inc.
InventorsEugene Medlock, Richard Yeh, Scott M. Silbiger, Gary S. Elliott, Hung Q. Nguyen, Shuqian Jing
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Abstract
The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.
Claims26
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) the nucleotide sequence comprising nucleotides 50 through 1729 of SEQ ID NO:
- 4;
- (b) the nucleotide sequence comprising nucleotides 50 through 1099 of SEQ ID NO:
- 4;
- (c) the nucleotide sequence comprising nucleotides 89 through 1099 of SEQ ID NO:
- 4;
- (d) the nucleotide sequence encoding the polypeptide comprising amino acids 1 through 560 of SEQ ID NO:
- 5;
- (e) the nucleotide sequence encoding the polypeptide comprising amino acids 1 through 350 of SEQ ID NO:
- 5;
- (f) the nucleotide sequence encoding the polypeptide comprising amino acids 14 through 350 of SEQ ID NO:
- 5;
- (g) the nucleotide sequence encoding the polypeptide having an amino acid sequence that is at least 90 percent identical to amino acids 14 through 350 of SEQ ID NO:
- 5, wherein the polypeptide binds IL-17;
- and
- (h) the nucleotide sequence fully complementary to any of (a)–(g).
An isolated host cell modified by transformation or transfection with a regulatory nucleic acid, wherein said regulatory nucleic acid is operatively linked to the nucleic acid comprising the nucleotide of SEQ ID NO:4.
A diagnostic reagent comprising a detectably labeled polynucleotide, wherein the polynucleotide encodes a polypeptide comprising the amino acid sequence selected from the group consisting of:
- (a) amino acids 1 through 560 of SEQ ID NO:
- 5,
- (b) amino acids 1 through 350 of SEQ ID NO:
- 5, and
- (c) amino acids 14 through 350 of SEQ ID NO:
- 5.
An isolated nucleic acid molecule comprising the nucleotide sequence of the cDNA clone contained in ATCC deposit number PTA-3176.
An isolated nucleic acid molecule comprising a nucleotide sequence, wherein the nucleotide sequence encodes a polypeptide comprising the extracellular domain of the amino acid sequence encoded by the cDNA clone contained in ATCC deposit number PTA-3177.
An isolated nucleic acid molecule comprising the nucleotide sequence of the cDNA clone contained in ATCC deposit number PTA-3178.
An isolated nucleic acid molecule comprising a nucleotide sequence encoding a polypeptide having an amino acid sequence that is at least 90 percent identical to amino acids 14 through 350 of SEQ ID NO:
- 5, wherein the polypeptide binds IL-17.
The isolated nucleic acid molecule comprising a nucleotide sequence encoding the polypeptide comprising amino acids 14 through 350 of SEQ ID NO:
- 5.
An isolated nucleic acid molecule comprising the nucleotide sequence comprising nucleotides 89 through 1099 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.