Diagnosis and treatment of malignant neoplasms
AssigneeRhode Island Hospital
InventorsJack R. Wands, Suzanne M de la Monte, Nedim Ince, Rolf I. Carlson
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Abstract
The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
Claims20
A method for diagnosing a malignant neoplasm in a mammal, comprising contacting a bodily fluid from said mammal with an antibody or fragment thereof which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide under conditions sufficient to form an antigen-antibody complex and detecting the antigen-antibody complex, wherein an increase in antigen-antibody complex indicates an increase in HAAH level compared to a normal noncancerous control, said increase being indicative of a malignant neoplasm and wherein said monoclonal antibody is produced by a hybridoma selected from the group consisting of hybridoma ATCC designation PTA 3383, hybridoma ATCC designation PTA 3384, and hybridoma ATCC designation PTA 3385.
A method of diagnosing a malignant neoplasm in a mammal, comprising contacting a bodily tissue from said mammal with an antibody or fragment thereof which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and detecting the antigen-antibody complex, wherein an increase in HAAH compared to a normal control indicates the presence of a malignant neoplasm and wherein said neoplasm is a hepatocellular carcinoma, wherein said antibody is produced by a hybridoma selected from the group consisting of hybridoma ATCC designation PTA 3383, hybridoma ATCC designation PTA 3384, and hybridoma ATCC designation PTA 3385.
A method of diagnosing a malignant neoplasm in a mammal, comprising contacting a bodily tissue from said mammal with an antibody or fragment thereof which binds to a HAAH polypeptide under conditions sufficient to form an antigen-antibody complex and detecting the antigen-antibody complex, wherein said antibody is produced by a hybridoma selected from the group consisting of hybridoma ATCC designation PTA 3383, hybridoma ATCC designation PTA 3384, and hybridoma ATCC designation PTA 3385 and wherein an increase in HAAH compared to a normal control indicates the presence of a malignant neoplasm.
Dependencies are inferred from the claim text.