Pectinophora gossypiella (pink bollworm) Bacillus thuringiensis toxin receptor BT-R2
AssigneeBoard of Regents, The University of Texas System
InventorsLee A. Bulla, Mehmet Candas
Life of this patent
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Abstract
A cDNA encoding a 200 kD receptor, BT-R2, from the pink boll worm, Pectinophora gossypiella, that binds specifically to a Bacillus thuringiensis toxin has been cloned, sequenced and characterized. The minimum toxin binding fragment has been identified. The BT-R2 cDNA permits the analysis of receptors in pink boll worm and other insects that affect crop growth and development, as well as, design assays for the cytotoxicity and binding affinity of potential pesticides. The clone and other methods described herein, permit the manipulation of natural and/or introduced homologous receptors and, thus, to specifically destroy organisms, tissues and/or cells of the target host.
Claims6
An isolated protein which binds cry1 A(c), wherein said protein comprises
- a) the amino acid sequence at positions 1269–1367 of SEQ. ID. No.:
- 2;
- or
- b) the amino acid sequence at positions 24–1729 of SEQ. ID. No.:
- 2.;
- or
- c) an amino acid sequence at least 95% homologous to positions 1–1729 of SEQ. ID. No.:
- 2.
Dependencies are inferred from the claim text.