Fibronectin biopolymer marker indicative of insulin resistance
AssigneeSyn X Pharma, Inc.
InventorsGeorge Jackowski, John Marshall
Life of this patent
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Abstract
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time- of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.
Claims9
An isolated biopolymer marker consisting of SEQ ID NO:3.
A method for determining in a patient sample, the presence of an isolated biopolymer marker consisting of SEQ ID NO:3 which is linked to insulin resistance comprising:
- (a) obtaining a sample from a patient;
- (b) conducting mass spectrometric analysis on said sample in a manner effective to maximize analysis of peptide fragments contained therein and comparing mass spectrum profiles of said isolated biopolymer marker consisting of SEQ ID NO:3 to mass spectrum profiles of peptides obtained and analyzed from said sample;
- and
- (c) confirming the presence of said isolated biopolymer marker consisting of SEQ ID NO:3 in said sample displaying a peak profile at about 1819 daltons in said mass spectrum profile;
- wherein the presence of said isolated biopolymer marker consisting of SEQ ID NO:3 is indicative of a link to insulin resistance.
A kit for determining the presence of an isolated biopolymer marker consisting of SEQ ID NO:3 comprising:
- (a) a peptide consisting of SEQ ID NO:3, and (b) an antibody that binds to said peptide in a sample from a patient.
Dependencies are inferred from the claim text.