Pharmaceutical composition as solid dosage form and method for manufacturing thereof

A method for manufacturing a pharmaceutical composition as a solid dosage form comprising desmopressin acetate, as a therapeutically active ingredient, wherein said method comprises the steps of:

• i) mixing desmopressin acetate and an excipient, diluent or carrier, or mixture thereof, optionally in the presence of a wetting agent, wherein at least one of said excipient, diluent and carrier is a disaccharide, wherein said disaccharide has an average particle size in the range of from 70 to 500 μm;
• ii) subjecting the resulting mixture to formation of a granulate, optionally in the presence of a wetting agent, suitable for compression into said solid dosage form;
• iii) optionally performing said mixing and/or formation of a granulate in the presence of at least one additive selected from a disintegrating agent, lubricant, binder, flavoring agent, preservative, colorant and a mixture thereof;
• iv) optionally drying said granulate;
• v) compressing said granulate into said solid dosage form, wherein said solid dosage form is a tablet.