US 7,094,544 B2Granted

Genetic test for the identification of carriers of complex vertebral malformations in cattle

AssigneesDanmarks Jordbrugsforskning, Kvaegavlsforeningen Dansire

InventorsChristian Bendixen, Søren Svendsen, Helle Jensen, Frank Panitz, Anders Aasberg, Lars-Erik Holm, Per Horn, Anette Høj, Bo Thomsen, Mette Jeppesen, Hunnicke Vivi Nielsen, Marck Jonker

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Abstract

Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at position 559 of the bovine SLC35A3 gene is identified as being causative and diagnostic for CVM in cattle.

Claims2

Dependent claims

A method for detecting bovine complex vertebral malformation (CVM) in a Holstein-Friesian subject said method comprising

a) providing a Holstein-Friesian genetic material comprising a coding sequence which encodes either
i) SEQ ID NO:17;
or
ii) a polypeptide which differs from SEQ ID NO:17 solely in that there is a phenylalanine at position 180, and
b) detecting, in the Holstein-Friesian subject genetic material, the presence or absence of complex vertebral malformation disease, wherein the presence of a coding sequence encoding polypeptide ii) is indicative of CVM.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/416,941Filed 15 Nov 2001
Priority: DK 2000 0171716 Nov 2000
Published: US 2004/0132032 A18 Jul 2004
Granted: 22 Aug 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C12Q 1/6883
Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes: for diseases caused by alterations of genetic material
C12Q 2600/156
Oligonucleotides characterized by their use: polymorphic or mutational markers
C12Q 2600/16
Oligonucleotides characterized by their use: primer sets for multiplex assays
C12Q 2600/172
Oligonucleotides characterized by their use: haplotypes