Detection of chromosoal abnormalities associated with breast cancer

A method of detecting an amplification or gain of unique sequences at at least one chromosomal region selected from the group consisting of:

• on human chromosome 1,
• about position p22 to the centromere;
• the q arm;
• the centromere to about position p32;
• about position q31 to qter;
• about position q32;
• about position q32 to qter;
• on human chromosome 2,
• the p arm;
• on human chromosome 3,
• about position p14;
• about position p14 to qter;
• about position p22 to pter;
• about position q26 to qter;
• on human chromosome 4,
• the p arm;
• about position q32 to about position q34;
• on human chromosome 5,
• the p arm;
• about position q31 to qter;
• about position q32 to qter;
• on human chromosome 6,
• the p arm;
• the centromere to about position p21;
• about position p23 to pter;
• the centromere to about position q21;
• about position q12 to about position q13;
• about position q21;
• about position q21 to about position q22;
• on human chromosome 7,
• the p arm;
• the centromere to about position p12;
• about position p21;
• pter to about position q31;
• the q arm;
• about position q22 to about position q32;
• on human chromosome 8,
• about position p12;
• the q arm;
• about position q21;
• about position q21 to about position q23;
• about position q21 to qter;
• about position q22 to about position q23;
• about position q22 to qter;
• about position q23 to about position q24;
• about position q23 to qter;
• about position q24;
• on human chromosome 10,
• the p arm;
• the centromere to about position q21;
• about position q22;
• on chromosome 11,
• about position p15;
• the q arm;
• about position q13;
• on human chromosome 12,
• the p arm;
• the q arm;
• about position q14 to about position q15;
• about position q21;
• about position q21 to about position q23;
• about position q24;
• on human chromosome 13,
• about position 22 to qter;
• about position q31 to qter;
• on human chromosome 14,
• the q arm;
• about position q24 to qter;
• about position q31;
• about position q31 to qter;
• on human chromosome 15,
• about position q21 to qter;
• about position q24;
• about position q25;
• about position q26;
• entire human chromosome 16;
• on human chromosome 16,
• the p arm;
• the q arm;
• about position q23 to about position q24;
• on human chromosome 17,
• the centromere to about position q24;
• about position q12;
• about position q21 to qter;
• about position q22 to about position q23;
• about position q22 to about position q24;
• about position q22 to qter;
• about position q24 to qter;
• on human chromosome 18,
• the p arm;
• on human chromosome 19,
• the q arm;
• about position q13;
• about position q13 to qter;
• entire human chromosome 20;
• on human chromosome 20,
• the p arm;
• the q arm;
• about position q12 to about position q13;
• about position q13;
• about position q13 to qter;
• about position q34;
• qter;
• entire chromosome 21;
• entire chromosome 22;
• on the human X chromosome,
• the p arm,
• in a test sample, said method comprising:
• (a) labelling nucleic acids from the test sample and from a control sample with different labels;
• (b) contacting said labelled nucleic acids from each sample with a plurality of target nucleic acids, wherein either the labelled nucleic acids or the target nucleic acids, or both, have had repetitive sequences, if initially present, blocked and/or removed;
• and
• (c) comparing the intensities of the signals from labelled nucleic acids hybridized to each target nucleic acid, thereby allowing detection of the presence or absence of the gain or amplification in the test sample.