Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer
AssigneeBoard of Regents of the University of Nebraska
InventorMing-Fong Lin
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Abstract
Presented is a therapeutic method to treat prostate carcinomas in mammals comprising the administration of cellular PAcP protein. Also presented is a method to diagnose androgen-insensitive prostate carcinomas by determining the expression level of cellular PAcP in the prostate carcinomas, a decrease in expression being indicative of androgen-insensitivity. A promoter region that is specifically expressed in prostate tissue is presented, as is a xenograft animal mode that mimics human prostate carcinomas in the expression of cellular PAcP.
Claims8
A method to diagnose androgen-insensitive prostate carcinomas comprising the step of determining the expression of cellular PAcP protein in the prostate carcinoma, a decrease in the expression being indicative of the androgen-insensitive nature of the carcinoma.
Dependencies are inferred from the claim text.